Tolerogenic Dendritic Cells: Key Regulators of Peripheral Tolerance in Health and Disease
نویسندگان
چکیده
منابع مشابه
Tolerogenic dendritic cells: key regulators of peripheral tolerance in health and disease.
Dendritic cells (DCs) as professional antigen-presenting cells are able to induce immunity and tolerance in different conditions, which leads to strong immune responses against hostile agents or tolerance to self-antigens. Although for subsets of DCs, a regulatory function has been shown, the role of the microenvironment is momentous to generate tolerogenic DCs (tDCs). Different microorganisms ...
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1Department of Tumor Immunology, Radboudumc, Nijmegen, Netherlands 2Enfermedades Hepaticas y Digestivas (CIBER), Barcelona, Spain 3Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA 4Center for Oncological Research and Laboratory of Experimental Hematology, University of Antwerp, Antwerp, Belgium 5Department of Laboratory Medi...
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Dendritic cells (DCs) are a heterogeneous family of professional APCs involved in priming adaptive immune responses. Donor DCs (direct pathway of allorecognition) and recipient DCs presenting processed donor major histocompatibility complex (MHC) as peptides (indirect pathway of allorecognition) participate actively in graft rejection by stimulating recipient T cell responses following organ tr...
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Dendritic cells (DCs) are bone marrow-derived cells of both lymphoid and myeloid stem cell origin that populate all lymphoid organs including the thymus, spleen, and lymph nodes, as well as nearly all nonlymphoid tissues and organs. Although DCs are a moderately diverse set of cells, they all have potent antigen-presenting capacity for stimulating naive, memory, and effector T cells. DCs are me...
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BACKGROUND Administration of interferon-α (IFN-α) represents an approved adjuvant therapy as reported for malignancies like melanoma and several viral infections. In malignant diseases, tolerance processes are critically involved in tumor progression. In this study, the effect of IFN-α on tolerance induction by human tolerogenic dendritic cells (DC) was analyzed. We focussed on tolerogenic IL-1...
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ژورنال
عنوان ژورنال: International Archives of Allergy and Immunology
سال: 2013
ISSN: 1423-0097,1018-2438
DOI: 10.1159/000350328